What are some genetic disorders associated with X-linked inheritance?
What are the different ways a genetic condition can be inherited?
| Inheritance pattern | Examples |
|---|---|
| X-linked dominant | fragile X syndrome |
| X-linked recessive | hemophilia, Fabry disease |
| X-linked | glucose-6-phosphate-dehydrogenase-deficiency, X-linked thrombocytopenia |
| Y-linked | Y chromosome infertility, some cases of Swyer syndrome |
Why can’t a son inherit an X-linked disorder from his father?
If a male who has an X-linked condition has a son, his son will never inherit the changed gene on the X chromosome. This is because men always pass on their Y chromosome to their sons (if they passed on their X chromosome they would have a daughter).
How is an X-linked recessive disorder inherited?
X-linked recessive inheritance is a way a genetic trait or condition can be passed down from parent to child through mutations (changes) in a gene on the X chromosome. In males (who only have one X chromosome), a mutation in the copy of the gene on the single X chromosome causes the condition.
What do males inherit from their mothers?
People usually have two copies of each chromosome. One copy is inherited from their mother (via the egg) and the other from their father (via the sperm). A sperm and an egg each contain one set of 23 chromosomes.
What is an example of recessive inheritance?
One example of a recessive inherited trait is a smooth chin, as opposed to a dominant cleft chin. Let (S) represent the dominant allele, and (s) represent the recessive allele.
When is a gene recessive?
A recessive gene is a gene that is not dominant but only manifests when a gene of both parents is the same, i.e., homozygous (where both genes are the same as in two genes for blue eyes).
What is X – linked dominant disease?
X-linked dominantdisorders are caused by mutations in genes on the X chromosome, one of the two sex chromosomes in each cell. In females (who have two X chromosomes), a mutation in one of the two copies of the gene in each cell is sufficient to cause the disorder.
What is X – linked genetic disease?
X-linked genetic conditions are genetic diseases affecting the sex chromosomes X and Y. They are called “x-linked” or “sex-linked” genetic conditions. (For comparison, non-sex chromosomes 1..22 are called “autosomes” and the resulting conditions called autosomal genetic diseases.) X-linked diseases can be recessive or dominant.
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