What is SDF-1 Alpha?

Stromal cell-derived factor 1 alpha (SDF1 alpha) and its cognate chemokine receptor CXCR4 act as potent chemoattractants and regulate trafficking and homing of hematopoietic progenitor cells and lymphocytes.

What is SDF disease?

Background: Peripheral artery disease is a potentially incapacitating disease for which pharmacological options are limited. Stromal cell-derived factor-1 (SDF-1) is a chemokine that attracts endothelial progenitor cells and promotes angiogenesis.

What is the receptor for CXCL12?

CXCL12 acts through its receptors CXCR4 and CXCR7. CXCR4 stimulation leads to the activation of numerous signaling pathways depending on the cell types while CXCR7 has mainly been shown to be involved in scavenging CXCL12, although it can activate a MAP kinase pathway through β-arrestin in several systems.

Which cells produce CXCL12?

CXCL12-Expressing Cells in Bone Marrow CAR cells are adipo-osteogenic progenitors, which express adipogenic and osteogenic genes, including peroxisome proliferator-activated receptor γ (PPARγ) and Osterix (Osx), and largely overlap with SCF-expressing cells predominantly expressing leptin receptor (Lepr) (13–15).

What type of protein is SDF-1?

cell-derived factor
Stromal cell-derived factor-1 (SDF-1) is a secreted 89-amino acid protein that binds chemokine receptor type 4 (CXCR4), a seven-pass G-protein-coupled membrane receptor. Several cell types, including osteoblasts, fibroblasts, and endothelial cells, express SDF-1.

Where is SDF-1 located?

Among them, the stromal cell derived factor-1 (SDF-1) gene, also known as CXC chemokine ligand 12 (CXCL12), has been widely studied4,5,6. The SDF-1 gene is located on chromosome 10q11. 1 and spans 10 kb7. The SDF-1 gene mainly encodes a CXC angiogenic chemokine8.

What are the stromal cells?

Listen to pronunciation. (STROH-mul sel) A type of cell that makes up certain types of connective tissue (supporting tissue that surrounds other tissues and organs).

What is CCR5 and CXCR4?

CXCR4 is the fusogenic receptor that promotes entry of T-tropic HIV-1 strains, while CCR5 allows entry of M-tropic HIV-1 strains (13–20). The importance of these findings recently has been underscored by the finding that individuals deficient in CCR5 remain uninfected in the face of high-risk exposure to virus (22–24).

Where is CXCR4 located?

CXCR4 is a G-protein-coupled seven transmembrane receptor that was originally cloned as an orphan chemokine receptor and was known as LESTR or fusin. CXCR4 is expressed on the cell surface of most leukocytes, including all B cells, and monocytes and most T lymphocyte subsets, but just weakly on NK cells.

Where is sdf1 located?

Where do stromal cells come from?

It is well known that stromal cells arise and are stored in the bone marrow until maturation and differentiation. They are located in the stroma and aid hematopoietic cells in forming the elements of the blood.

Are stromal cells cancerous?

Tumor stroma, broadly defined as the non-cancer cell and non-immune cell components of tumors, is viewed traditionally as the structural components holding tumor tissues together.

What type of cells express stromal cell derived factor 1?

Stromal Cell-Derived Factor-1 Stromal cell-derived factor-1 (SDF-1) is a secreted 89-amino acid protein that binds chemokine receptor type 4 (CXCR4), a seven-pass G-protein-coupled membrane receptor. Several cell types, including osteoblasts, fibroblasts, and endothelial cells, express SDF-1.

What are stromal cell-derived factors 1-alpha and 1-beta?

Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The chemokines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds.

What is SDF-1?

SDF-1 is a naturally occurring chemokine that is rapidly increased in post-infarction tissue injury to promote stem cell homing to the myocardium. SDF-1 enhances tissue repair by preventing cell death and recruiting blood borne and tissue-specific stem cells to the damaged region.

Is the sdf-1-cxcr4 axis involved in cancer stem cell trafficking?

“Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis”. Stem Cells. 23 (7): 879–94. doi: 10.1634/stemcells.2004-0342.