What does WT1 positive mean?

WT1-positive tumors included tumor of the stomach, prostate, and biliary and urinary systems, and malignant melanomas. A majority of the positive cases showed diffuse or granular staining in the cytoplasm, whereas ovarian tumors and desmoplastic small round cell tumors frequently showed nuclear staining.

What does WT1 negative mean?

Scoring of WT1 was assigned according to the intensity of the staining using a 4-tiered scale and graded as 0 (negative; with <25% cells positive), 1+ (weak; 25–50% positive cells), 2+ (moderate; 51–75% positive cells), or 3+ (strong; >75% positive cells).

What does PAX8 positive mean?

PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).

What does WT1 stand for?

Abstract. The Wilms’ tumor 1 (WT1) gene encodes a transcription factor important for normal cellular development and cell survival.

What is CDX2 positive?

These results suggest that positive CDX2 staining represents a highly sensitive and specific marker of metastatic colorectal carcinoma in both biopsy and resected specimens, and is superior to staining for the CK7-/20+ phenotype.

What is high grade serous carcinoma?

What is a high grade serous cancer? A: High-grade serous carcinomas are distinct neoplasms with different pathogenesis, behavior, and response to treatment than low grade tumours. They are aggressive tumours that usually grow quickly and spread widely before diagnosis.

What does the WT1 gene do?

The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 protein activity is limited to a structure known as the glomerulus, which filters blood through the kidneys.

What is WT1 mutation?

Mutations of Wilms’ tumor suppressor gene1 (WT1) are associated with embryonic malignancy of the kidney, affecting around 1-9 in 100,000 infants. It occurs in both sporadic and hereditary forms. Inactivation of WT1 causes Wilms tumour, and Denys-Drash syndrome (DDS), leading to nephropathy and genital abnormalities.

What tumors are positive for PAX8?

These results show that PAX8 is a highly sensitive marker for thyroid, renal, Müllerian, and thymic tumors. Importantly, all lung adenocarcinomas, breast and adrenal neoplasms, and the majority of gastrointestinal tumors were negative for PAX8. Therefore, PAX8 is an excellent marker for confirming primary tumor site.

What does GATA3 positive mean?

In univariate analysis, the presence of GATA-3 is a marker of good prognosis and predicted for superior breast cancer-specific survival, relapse-free survival, and overall survival.

What is WT1 marker?

Aims: Wilms tumor protein 1 (WT1) expression is used in gynecological pathology as a diagnostic marker of serous differentiation, and is frequently co-expressed with ER-α. Early phase studies on WT1 vaccine in gynecological cancers are ongoing.

What does WT1 gene do?

Which ovarian tumors are associated with Wolff-Parkinson-White (WT1) 1 (wpw1) syndrome?

Among ovarian tumors, WT1 expression was seen in 24 of 28 serous and 4 of 18 clear cell carcinomas, but in none of 11 endometrioid and 11 mucinous tumors. All 12 serous carcinomas but none of 2 endometrioid carcinomas of the fallopian tube were positive for WT1. WT1 expression was seen in 19 of 20 serous primary peritoneal carcinomas.

Does WT1 expression correlate with clinico-pathologic characteristics in epithelial ovarian cancer?

The aim of this study was to determine the expression of WT1 in epithelial ovarian cancer (EOC) and correlate with clinico-pathologic characteristics. Methods: WT1 expression was examined using immunohistochemistry applied on a tissue microarray of normal tissues and a panel of 100 EOC tissues.

What is the role of Wolff-parkinson-1 (WT1) in serous carcinomas of the endometrium?

Although its biologic role is still unclear, most serous carcinomas of the ovary and peritoneum, mesotheliomas, and Wilms’ tumor have been shown to express WT1. A recent study, however, found no WT1 expression in serous carcinomas of the endometrium, suggesting that WT1 could be useful in identifying the primary site of serous carcinomas.

Is there a relationship between p53 and WT1 expression in carcinomas?

A significant positive correlation was found between the level of p53 and WT1 expression in all carcinomas combined (r = 0.3935, p<0.0001, Spearman test), but when only serous carcinomas were analyzed, the correlation between p53 and WT1 expression levels did not reach statistical significance.