What does the Klotho gene do?

Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family.

What is the function of Klotho protein?

Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection.

Could a protein called Klotho block dementia and aging?

In both humans and mice, she found the same result: more klotho meant better cognitive function. Aging is the biggest risk factor for cognitive problems, and cognitive problems are one of the biggest biomedical challenges that we face.

What is Klotho?

Function. Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in ageing. Its discovery was documented in 1997 by Makoto Kuro-o et al.

How was Klotho discovered?

KL gene localization. The Klotho (KL) gene encodes the α-Klotho protein. Information about the KL gene and its protein is provided in Table 1. The KL gene was identified by Kuro-o et al (1) in 1997 through a spontaneous mutation of the α-Klotho promoter region of α-Klotho.

What is Klotho deficiency?

Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int.

What chromosome is Klotho on?

A. The KL gene was identified by Kuro-o et al (1) in 1997 through a spontaneous mutation of the α-Klotho promoter region of α-Klotho. The mouse KL gene locus is located on chromosome 5 (Figure 1) and flanked by PDS5B and STARD13.

Does everyone have the Klotho gene?

Klotho was discovered in 1997 and named after the Fate from Greek mythology who spins the thread of life. The investigators found that people who carry a single copy of the KL-VS variant of the KLOTHO gene, roughly 20 percent of the population, have more klotho protein in their blood than non-carriers.

Is Klotho a gene?

KL (Klotho) is a Protein Coding gene. Diseases associated with KL include Tumoral Calcinosis, Hyperphosphatemic, Familial, 3 and Tumoral Calcinosis, Hyperphosphatemic, Familial, 1. Among its related pathways are RET signaling and Downstream signaling of activated FGFR2.

What chromosome is klotho on?

How can I increase my klotho level?

Pharmacologic means to increase endogenous Klotho levels include phosphate restriction, vitamin D, angiotensin-converting enzyme inhibitor, peroxisome proliferator-activated receptor-gamma agonists (thiazolidinediones), 3-hydroxy-3-methylglutaryl CoA reductase inhibitors; all currently approved for clinical use for …

How can I increase my Klotho level?

What is the Klotho gene?

Klotho is an anti-aging gene originally identified in 1997 [ 6 ]. Kuro-o et al. [ 6, 7] found that Klotho-deficient mice developed multiple premature aging syndromes, whereas overexpression of Klotho extended the lifespan of mice. The Klotho gene is located in chromosome 13q12 in human with the size of 50 kb [ 6 ].

Is Klotho downregulated with age?

In fact, Klotho was recently identified as one of the genes whose expression was significantly down-regulated with age in the brain of rodents and primates (rhesus monkey) [27]. 4. Klotho protein functions The klothogene encodes a single-pass transmembrane protein.

How do defects in Klotho and FGF23 gene expression affect phosphate metabolism?

Defects in either Klotho or Fgf23 gene expression cause not only phosphate retention but also a premature-aging syndrome in mice, unveiling a potential link between phosphate metabolism and aging. In addition, the extracellular domain of Klotho protein is clipped on the cell surface and secreted into blood stream,…

Is the Klotho gene regulated by PPAR-gamma?

Klotho is a target gene of PPAR-gamma Klotho is an anti-aging gene whose expression is regulated by many stimuli. Here we examined the transcriptional regulation of the klotho gene by peroxisome proliferator-activated receptor-gamma (PPAR-gamma). The PPAR-gamma agonists thiazolidinediones increased both klotho mRNA and protein expressio …