What does GATA4 stand for?
GATA binding protein 4
|Aliases||GATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF|
|External IDs||OMIM: 600576 MGI: 95664 HomoloGene: 1551 GeneCards: GATA4|
|showGene location (Human)|
|showGene location (Mouse)|
Where is GATA4 expressed?
As the follicle develops, GATA4 becomes uniformly expressed in healthy follicles and is expressed in granulosa and theca cells of secondary and antral follicles and to a lesser degree in stromal cells (Anttonen et al., 2003; Heikinheimo et al., 1997; Laitinen et al., 2000; Vaskivuo et al., 2001; Viger et al., 1998).
Is GATA4 transcription factor?
GATA4 is a member of the GATA family of zinc finger transcription factor, which regulates gene transcription by binding to GATA elements. GATA4 was originally discovered as a regulator of cardiac development and subsequently identified as a major regulator of adult cardiac hypertrophy.
What protein does GATA4 produce?
Data show that the combination of GATA binding protein 4 (Gata4), T-box transcription factor 5 (Tbx5) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes.
What is gata 2 mutation?
GATA2 deficiency is caused by germline mutations in the GATA2 gene. Germline means that the mutation is present in every cell in the body, not just the immune system cells. The GATA2 gene produces a protein called a transcription factor. Transcription factors regulate when other genes are turned on.
What is GATA2 Haploinsufficiency?
The mechanism underlying GATA2 deficiency is called “haploinsufficiency.” This means that having one mutated copy of GATA2 and one working copy of GATA2 is insufficient for normal functioning of the hematopoietic, or blood- making, system. Many different germline GATA2 mutations have been reported.
When was GATA2 discovered?
While only genetically discovered in 2011, GATA2 deficiency is an increasingly recognized entity, and further mechanistic and natural history clinical studies will provide greater understanding regarding these challenging patients.
What does GATA3 positive mean?
In univariate analysis, the presence of GATA-3 is a marker of good prognosis and predicted for superior breast cancer-specific survival, relapse-free survival, and overall survival.
What is GATA2 mutation?
Is GATA3 positive good or bad?
Based on the DFS analysis, GATA3-positive expression was significantly associated with worse DFS in univariate analysis (hazard ratio [HR], 2.719; P = 0.012). GATA3-positive expression was also identified as an independent risk factor for recurrence in multivariate analysis (HR, 2.711; P = 0.014).
Studied prevalence of GATA binding protein 4 (GATA4) exon 1 mutation in Egyptian patients with isolated congenital heart defects. The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2.
What is Gata4 (GATA binding protein 4)?
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2 .
What is the pathophysiology of GATA4?
Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2 . Among its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Metabolism of proteins .
Is GATA-4 a sumo-1-targeted transcription factor?
GATA4 is a SUMO-1-targeted transcription factor and together with PIAS1 is a potent regulator of cardiac gene activity GATA-4 and GATA-6 mRNAs are readily detectable from gestational week 19 in human adrenal cortex. expression of GATA-4 and GATA-6 is up-regulated prior to the transcriptional activation of Nkx 2.5 during cardiogenesis