What are polymeric micelles?
Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. Relevant properties discussed include micellar association, morphology, size and stability.
What are types of micelles?
Micelles are usually spherical ranging in size from 2 to 20 nm depending on composition. The most common methods for micelle preparation include oil in water emulsion [98,99], solvent evaporation [100,101], solid dispersion, and dialysis methods [97,102].
What are polymeric micelles used for?
Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. With small size (10–100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit prolonged circulation time in the blood and enhanced tumor accumulation.
What are micelles in pharmacy?
4 Micelles. Micelles are spherical amphiphilic structures that have a hydrophobic core and a hydrophilic shell. 155. The hydrophilic shell makes the micelle water soluble that allows for intravenous delivery while the hydrophobic core carries a payload of drug for therapy.
What are the two categories of polymers?
Polymers fall into two categories:
- thermosetting plastic or thermoset.
- thermoforming plastic or thermoplastic.
What are polymeric nanoparticles?
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure.
What are micelles give examples?
Give an example of a micellers system. Answer: Micelle formation is done by substance such as soaps and detergent when dissolved in water. The molecules of such substance contain a hydrophobic and hydrophillic part.
What is the difference between micelles and chylomicrons?
The key difference between micelles and chylomicrons is that micelles are globules of lipid molecules that are arranged in a spherical form in an aqueous solution while chylomicrons are lipoproteins that consist of a core made from triglycerides and cholesterols and a coat made from phospholipids and apolipoproteins.
What is the difference between micelle and liposome?
Liposomes are composed of a lipid bilayer separating an aqueous internal compartment from the bulk aqueous phase. Micelles are closed lipid monolayers with a fatty acid core and polar surface, or polar core with fatty acids on the surface (inverted micelle).
Why do surfactants form micelles?
The cohesive forces between the water molecules are very strong making the surface tension of water high. The intermolecular forces between surfactant and water molecule are much lower than between two water molecules and thus surface tension will decrease. When the surfactant concentration is high, they form micelles.
What are the 4 types of polymers?
Terms. Synthetic polymers are human-made polymers. From the utility point of view, they can be classified into four main categories: thermoplastics, thermosets, elastomers, and synthetic fibers.
Are polymeric micelles a new drug carrier system?
In the last two decades, polymeric micelles have been actively studied as a new type of drug carrier system, in particular for drug targeting of anticancer drugs to solid tumors.
Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes.
What drugs can peg micelles solubilize?
These micelles can solubilize many types of poorly water-soluble drugs including paclitaxel (2), tamoxifen (2), porphyrin (2), camptothecin (22), and vitamin K3 (23). The PEG-PE micelles exhibit favorable stability, longevity in blood and tumor accumulation via the EPR effect (20,24).
What are hydrotropic polymer micelles used for in drug delivery?
Kim JY, Kim S, Pinal R, Park K. Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs. J Control Release.