Is PTPRZ1 a tyrosine phosphatase?

PTPRZ1 was highly expressed in human neuroendocrine tumor tissues and PTPRZ1 is an oncogenic tyrosine phosphatase in small-cell lung carcinoma. Receptor-type Protein tyrosine phosphatase beta regulates met phosphorylation and function in head and neck squamous cell carcinoma.

Is ptprz1-met fusion associated with glioblastoma malignant growth?

High PTPRZ1 expression is associated with glioblastoma. Molecular crosstalk between tumour-associated macrophages and glioma stem cells through PTN-PTPRZ1 paracrine signalling supports glioblastoma malignant growth. Authors characterized exosomes from GBM cells harbouring and not harbouring PTPRZ1-MET fusion (ZM fusion).

What does pptprz1 stand for?

5803 – Gene ResultPTPRZ1 protein tyrosine phosphatase receptor type Z1 [ (human)] This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS.

What does PTP-Zeta stand for?

Protein tyrosine phosphatase zeta enhances proliferation by increasing beta-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells. Data suggest that CSF-1R-independent actions of IL-34 via receptor-type protein-tyrosine phosphatase zeta (PTP-zeta) might be considered in evaluating IL-34 roles in development and disease.