How do you synthesize Methcathinone?

The synthesis of methcathinone is generally accomplished by oxidation of ephedrine-type compounds using either dichro mate or permanganate (Scheme 1). Ephedrine and pseu doephedrine yield methcathinone upon oxidation of the ben- zylic hydroxyl group to the corresponding carbonyl-containing aminoketone.

How is Methcathinone administered?

Anecdotal reports have provided some information on patterns of methcathinone use. The most common route of administration is via nasal insufflation (snorting). Other routes of administration include per os, IV injection and smoking.

What is in Methcathinone?

Methcathinone, a methyl derivative of cathinone, is an illicit drug also known as ephedrone. It is a stimulant found in the “khat” plant, Catha edulis, which can easily be synthesized from pseudoephedrine.

How do you oxidize ephedrine?

Pseudoephedrine contained in pills is oxidized using potassium permanganate and an acetic acid milieu [4, 5] or, alternatively, using potassium dichromate in sulfuric acid [6].

How do you synthesize ephedrine?

Natural ephedrine is prepared by extraction from Ephedra plants. This process is typically employed for ephedrine manufactured in China. Semi-synthetic ephedrine is prepared by fermentation of sugar followed by amination, a process known to be used in India. Fully chemically synthesized ephedrine is produced elsewhere.

What are the side effects of cat?

Long-term effects

• Paranoia.
• Hallucinations.
• Anxiety followed by depression.
• Tremors and convulsions.
• Anorexia, malnutrition, and weight loss.
• Dehydration and electrolyte imbalance.
• Stomach pains.
• Nausea.

How long does khat stay in your system?

How Long Does Khat Stay in Your System? Once consumed, the effects of khat peak after approximately 15 to 30 minutes. The drug has a half-life of approximately three hours.

What is methcathinone?

Methcathinone, a methyl derivative of cathinone, is an illicit drug also known as ephedrone. It is a stimulant found in the “khat” plant, Catha edulis, which can easily be synthesized from pseudoephedrine. Its intoxication is difficult to diagnose and cure properly for two reasons: (i) target consum …

How do you make cathinone and methcathinone?

Cathinone can be extracted from Catha edulis or synthesized from α-bromopropiophenone, a compound that can be made from propiophenone. Methcathinone can be prepared from oxidation of ephedrine. Even the chiral synthesis of these materials has been reported, using amino acids as precursors, with ease.

Are synthetic cathinones related to amphetamine?

Typically, synthetic cathinones have an amphetamine-type analogue, i.e., cathinone, methcathinone, and methylone are structurally related to amphetamine, methamphetamine, and 3,4-methylenedioxy-methamphetamine, respectively ( Kelly, 2011 ).

What is the difference between methcathinone and ephedrone?

The name Methcathinone is derived from the name of the drug cathinone, obviously, which in turn is derived from “cathine”, an alternate name for norpseudephedrine, an isomer of phenpropanolamine. The name “Ephedrone” is obviously derived from the fact that “Ephedrone” is the ketone of the alcohol that is Ephedrine.