Does cidofovir cover CMV?

Does cidofovir cover CMV?

Ganciclovir, foscarnet, and cidofovir are antiviral drugs approved for use against cytomegalovirus (CMV) in adults by the US Food and Drug Administration. They have a broad spectrum of antiviral activity and are accordingly used for treatment of other viral infections, including herpes simplex viruses.

What is the treatment for congenital CMV?

Treatment. For infants with signs of congenital CMV disease at birth, antiviral medications, such as ganciclovir or valganciclovir, may improve hearing and developmental outcomes. Ganciclovir can have serious side effects and has only been studied in infants with symptomatic congenital CMV disease.

Can CMV be cured in babies?

Newborns may develop neurologic problems such as hearing loss. Handwashing can help prevent spread of the virus. Cytomegalovirus infection cannot be cured, but some antiviral drugs can limit the problems caused by infection.

How is neonatal CMV treated?

Symptomatic congenital CMV infection should be treated with ganciclovir or valganciclovir for 6 months to reduce or ameliorate long-term neurologic deficits, including hearing loss and developmental delay. Studies suggest that some infants with asymptomatic congenital CMV infection may benefit from treatment.

What does cidofovir treat?

Cidofovir is an antiviral medication that prevents certain viral cells from multiplying in your body. Cidofovir is used to treat an eye infection called cytomegalovirus retinitis (CMV) in people who have AIDS (acquired immunodeficiency syndrome).

When do you treat CMV viremia?

In preemptive therapy, CMV viremia is monitored and treatment is initiated when CMV viremia reaches a specified threshold, most frequently before the patient becomes symptomatic. Prophylaxis is offered to patients during the period of highest risk of infection to prevent development of CMV viremia and disease.

How long does it take for cidofovir to work?

Cidofovir can harm your kidneys after only one or two doses. Your IV fluids may be given for up to 3 hours before and after you receive your cidofovir injection. This IV treatment can take up to 6 hours to complete.

How do you use cidofovir?

It is usually given once every 2 weeks. The length of treatment depends on your body’s response to the medication. You must take probenecid tablets by mouth with each dose of cidofovir. Take a dose of probenecid 3 hours before receiving cidofovir injection and again 2 and 8 hours after your infusion is completed.

What is Cidofovir used to treat?

The drug has been employed almost exclusively to treat cytomegalovirus (CMV) infections in patients with the acquired immunodeficiency syndrome (AIDS) and transplant recipients. However, cidofovir is also used as a therapeutic option against other viral infections.

Is Cidofovir effective in the treatment of cytomegalovirus (CMV) retinitis?

In addition to delaying the progression of CMV retinitis, cidofovir may provide some protective benefits to patients at risk for developing the disease and may be active against certain st … Cidofovir in the treatment of cytomegaloviral disease Ann Pharmacother. 1998 Nov;32(11):1181-92.doi: 10.1345/aph.17312. Authors

Is valganciclovir effective in the treatment of congenital cytomegalovirus (CMV) infections?

Second, the treatment of congenital CMV infections with valganciclovir has beneficially improved both hearing and neurologic outcomes, both fundamental advances for these children. In these pediatric studies, viral load was decreased but not eliminated.

What are the indications for therapy for cytomegalovirus (CMV) disease?

The indications for therapy were cytomegalovirus (CMV) disease in 20 patients, primary preemptive therapy in 24 patients, and secondary preemptive therapy in 38 patients. Of the patients, 47 had received previous antiviral therapy with ganciclovir, foscarnet, or both drugs.