What is trastuzumab?

Trastuzumab is a targeted cancer drug and is also known by other names such as Herceptin, Herzuma and Ontruzant. It is a treatment for early and advanced breast cancer, advanced stomach cancer and cancer of where the food pipe joins your stomach (gastro oesophageal junction).

What is the function of trastuzumab?

Trastuzumab is a monoclonal antibody that is used in the treatment of breast cancer. Trastuzumab targets the human epidermal growth factor receptor 2 (HER2) receptor on breast cancer cells that express this tyrosine kinase receptor. These cancers are referred to as HER2-positive breast cancer.

Is trastuzumab a chemotherapy drug?

Trastuzumab is used to treat metastatic (spread) breast cancer. It is effective against tumors that overexpress the HER2/neu protein. As part of chemotherapy regimen for adjuvant treatment of lymph-node positive, HER2/neu protein positive breast cancer.

Is trastuzumab chemotherapy or immunotherapy?

These are active specific immunotherapy with Theratope and passive immunotherapy targeting the HER-2 receptor with trastuzumab (Herceptin). Trastuzumab has a proven efficacy as monotherapy as well as in combination with chemotherapeutic agents in HER-2-overexpressing metastatic breast cancer.

Is trastuzumab a pill?

Trastuzumab is used to treat certain types of breast, stomach, or esophagus cancer. This medication is used to treat tumors that produce more than the normal amount of a certain substance called HER2 protein. Trastuzumab belongs to a class of medications known as monoclonal antibodies.

Is trastuzumab an immunotherapy?

Passive immunotherapy has provided several successful treatments for breast cancer. The current mainstay of passive immunotherapy includes trastuzumab, pertuzumab, and trastuzumab emtansine (T-DM1).

What is the generic name of trastuzumab?

Herceptin is the trade name for Trastuzumab. In some cases, health care professionals may use the trade name Herceptin when referring to the generic drug name Trastuzumab. Drug type: Herceptin is a monoclonal antibody. (For more detail, see “How this drug works” section below).

Does trastuzumab cause hair loss?

Answer: No, hair loss is not a common side effect of trastuzumab. If you are receiving trastuzumab in combination with chemotherapy, you may experience hair loss due to the chemotherapy.

What is trastuzumab made from?

The active substance trastuzumab is produced in recombinant Chinese Hamster Ovary cells using a serum free medium. The MCB, WCB and End of Production Cells were characterised sufficiently. MCB andWCB were adapted to growth in serum free medium.

How much does trastuzumab cost?

Results. Trastuzumab costs $49,915 and $28,350 per patient treated in the adjuvant and metastatic breast cancer settings, respectively; bevacizumab costs $48,490 and $39,614 per patient treated in the metastatic lung and colorectal cancer settings, respectively.

How effective is trastuzumab?

Our findings and meta-analysis results revealed that trastuzumab is effective in increasing OS (OS hazard ratio: -0.286 ± 0.049, 95%CI (-0.381, – 0.191)) and improving DFS (DFS hazard ratio: -0.419± 0.077, 95%CI (-0.569, -0.269)). The most serious but negligible side effect of trastuzumab is congestive heart failure.

What drug class is trastuzumab?

Trastuzumab injection products are also used with other medications to treat certain types of stomach cancer that have spread to other parts of the body. Trastuzumab is in a class of medications called monoclonal antibodies. It works by stopping the growth of cancer cells.

Is trastuzumab immunotherapy or chemotherapy?

Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer. Specifically it is used for breast cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication.

Is trastuzumab immunotherapy?

In our patient, IT trastuzumab immunotherapy improved prognosis and was an effective strategy to manage HER-2+ LM disease. Given alone or alongside other anti-HER-2+ therapeutics with sufficient CNS penetration, IT trastuzumab could extend the lifespan of patients with leptomeningeal and CNS metastases.

How does trastuzumab work?

How trastuzumab works. Trastuzumab is a type of targeted therapy drug called a monoclonal antibody. It works by ‘targeting’ specific proteins on the surface of cells. Some cancers have too much of a protein called HER2 (human epidermal growth factor receptor 2) on the surface of their cells.