What is the SOD2 A16V gene?

Recently, a single nucleotide polymorphism of the gene coding for mitochondrial superoxide dismutase (SOD2), namely the missense substitution A16V (C47>T) resulting in alteration of SOD2 enzyme activity, has been reported to be associated with MCS.

What does SOD2 gene do?

SOD2 transforms superoxide produced by the mitochondria into the less toxic hydrogen peroxide and oxygen. This allows SOD2 to clear mitochondrial reactive oxygen species (ROS) and confer some protection against cell death [2, 1].

Is SOD2 an antioxidant?

Superoxide dismutase 2 (SOD2) is one of the major antioxidant defense systems against free radicals. Ala16Val SNP and changes in the activity of the SOD2 antioxidant enzyme have been associated with altered progression and risk of different diseases.

Where is SOD2 produced?

mitochondrial matrix
SOD2 is located within the mitochondrial matrix, the main site of free radical production from the electron transport chain (22).

What is the function of glutathione peroxidase?

Glutathione Peroxidase (GPx) is a cytosolic enzyme that catalyzes the reduction of hydrogen peroxide to water and oxygen as well as catalyzing the reduction of peroxide radicals to alcohols and oxygen.

What is the role of superoxide dismutase?

Superoxide dismutases (SODs) constitute a very important antioxidant defense against oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive oxygen species-mediated diseases.

Is SOD2 produced in the mitochondria?

SOD2 is located within the mitochondrial matrix, the main site of free radical production from the electron transport chain (22).

What is SOD1 gene?

The SOD1 gene provides instructions for making an enzyme called superoxide dismutase, which is abundant in cells throughout the body. This enzyme attaches (binds) to molecules of copper and zinc to break down toxic, charged oxygen molecules called superoxide radicals.

What are the symptoms of glutathione deficiency?

The signs and symptoms of the deficiency may include anemia , the buildup of too much acid in the body (metabolic acidosis), frequent infections, and symptoms caused by problems in the brain including seizures , intellectual disability , and loss of coordination ( ataxia ).

What is the difference between glutathione and glutathione peroxidase?

Glutathione, which is involved in the transport of amino acids, acts as a coenzyme for enzymes and it protects against oxygen radicals and toxic compounds [5]. Se- dependent GSH peroxidase is capable of utilizing hydrogen peroxide (H2O2) and a variety of organic hydroperoxides as substrates.

What disease is associated with a lack of superoxide dismutase?

In mice, the extracellular superoxide dismutase (SOD3, ecSOD) contributes to the development of hypertension. Diminished SOD3 activity has been linked to lung diseases such as Acute Respiratory Distress Syndrome (ARDS) or Chronic obstructive pulmonary disease (COPD).

What is the rs4880 (T) allele?

? The rs4880 (T) allele, part of the codon for amino acid valine at codon 16 of the antioxidant protein from the mitochrondrial superoxide dismutase 2 SOD2 gene, is the most common in most populations studied. The rs4880 (C) allele gives rise to an alanine at this position is it also known as Val16Ala manganese superoxide dismutase, or A16V.

What is the SOD2 gene?

The SOD2 gene is a member of the iron/manganese superoxide dismutase family. This protein transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain, into hydrogen peroxide and diatomic oxygen. The more energy your mitochondria produce, the more byproducts (free radicals) get produced.

Does SOD2 rs4880 CT/CC genotype predict poor survival in gastric cancer?

[ PMID 25901207] SOD2 rs4880 CT/CC genotype predicts poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy [ PMID 25417767] Association of SOD2 polymorphisms with primary open angle glaucoma in a Chinese population

What is SOD2 mimetic?

My recollection is that it’s a mimetic – meaning that it mimics SOD2. so it’s a little like hormone replacement. some people take hormones when their body doesn’t make enough. In the same way some people take Fullerene when their body doesn’t make enough SOD2. Kellysays: