What is fibrotic liver disease?

What is fibrotic liver disease?

Fibrosis is the formation of an abnormally large amount of scar tissue in the liver. It occurs when the liver attempts to repair and replace damaged cells. Many conditions can damage the liver. Fibrosis itself causes no symptoms, but severe scarring can result in cirrhosis.

What is the life expectancy of liver fibrosis?

Compensated cirrhosis: People with compensated cirrhosis do not show symptoms, while life expectancy is around 9–12 years. A person can remain asymptomatic for years, although 5–7% of those with the condition will develop symptoms every year.

Can the liver recover from fibrosis?

In mild to moderate liver fibrosis, treating the underlying cause can often reverse some or all of the damage. The liver may heal more slowly or quickly, depending on the cause of the fibrosis and its severity.

How long can you live with a compensated liver?

Patients with compensated chronic liver failure (without ascites, variceal bleeding, encephalopathy, or jaundice) have a median survival of 12 years. After decompensation, median survival drops to ~ 2 years.

Does compensated cirrhosis always progress decompensated?

Progression of disease is rapid with the rate of decompensation in patients with compensated cirrhosis being 11% per year, but is particularly rapid in the first year following diagnosis at 31% in this first year.

How long can you have compensated cirrhosis?

Diagnosis of cirrhosis heralds an increased risk of liver-related morbidity and overall mortality. The median survival of patients with compensated cirrhosis is approximately 9 to 12 years, whereas the median survival among patients with decompensated cirrhosis drops significantly to approximately 2 years.

What is the difference between liver fibrosis and cirrhosis?

Liver fibrosis occurs when the healthy tissue of your liver becomes scarred and therefore cannot work as well. Fibrosis is the first stage of liver scarring. Later, if more of the liver becomes scarred, it’s known as liver cirrhosis.

What is the difference between compensated cirrhosis and fibrosis?

Moderate liver damage is called fibrosis, while severe liver damage is called compensated cirrhosis. However, when there is liver failure, it is called decompensated cirrhosis. Usually, medical tests would determine the stage or grade of liver damage if there is any.

What is compensated cirrhosis of the liver?

Compensated cirrhosis is generally the early stage of liver cirrhosis, or chronic liver disease. A person with this stage of cirrhosis likely has liver scarring or discoloration, but the liver still generates enough healthy cells to function normally.

Is liver fibrosis related to prognosis?

LIVER FIBROSIS AND CIRRHOSIS Because liver fibrosis is positively related to prognosis, accurate staging of liver fibrosis gives important clinical implications in the management of chronic liver disease[16].

Is liver fibrosis a dynamic process?

Liver fibrosis is a common histological change of chronic liver injury and it is closely related with portal hypertension which is hemodynamic complication of chronic liver disease. Currently, liver fibrosis has been known as a reversible dynamic process in previous literatures.