What is drug-coated balloon used for?

What is drug-coated balloon used for?

Drug-coated balloons (DCB), also referred to as drug-eluting balloons (DEB), were created as a way to reduce very high restenosis rates in peripheral vessels. They also have been investigated in clinical trials to prevent coronary artery in-stent restenosis.

What are limus drugs?

Limus drugs are cytostatic, rather than cytotoxic, which means that the cell becomes inhibited from proliferation if therapeutic tissue levels are maintained over time. Conversely, paclitaxel is a cytotoxic drug, which means it essentially induces smooth muscle cell death and has potential for toxicity.

How long does a drug-coated balloon last?

More than 80% of the drug is retained during balloon delivery to the target lesion, and 10% to 15% of the initial dose is delivered to the vessel wall on 60-second inflation. Paccocath coating is stable during ethylene oxide sterilization, and the balloon has >1 year shelf life. B.

What is drug-coated balloon catheter?

Non-stent-based delivery such as drug-coated balloons (DCBs) that can deliver drugs to inhibit ISR or to de novo lesions, are emerging at a rapid pace. DCBs carry an active drug and a nonpolymeric carrier molecule or excipient that enhance the bioavailability of the drug to the vessel wall.

Is sirolimus the same as rapamycin?

Sirolimus, also known as rapamycin or by the brand name Rapamune, is a medicine that lowers the body’s natural immunity. The immune system response is thought to be involved in Nephrotic Syndrome. It is also used to prevent rejection of transplanted organs, such as the kidney, heart, and liver.

What is stent restenosis?

In-stent restenosis (ISR) is the narrowing of a stented coronary artery lesion. The mean time from percutaneous coronary intervention (PCI) to ISR was 12 months with drug-eluting stents (DES) and 6 months with bare metal stents (BMS). ISR typically presents as recurrent angina.

What medication is in drug-eluting stent?

DES consist of a standard metallic stent, a polymer coating, and an antirestenotic drug that is mixed within the polymer and released over time. First-generation DES include sirolimus-eluting stents (SES; 2003) and paclitaxel-eluting stents (PES; 2004) (TABLE 1).

What are stents coated in?

Silicon carbide is an inert semiconductor that can be coated onto prosthetic surfaces and has been shown to be relatively biocompatible and hemocompatible in in vitro studies. Stents coated with silicon carbide also appear to be less thrombogenic than bare metal stents when implanted in human coronary arteries.

What kind of drug is sirolimus?

Sirolimus is in a class of medications called immunosuppressants. It works by suppressing the body’s immune system.