What is balo concentric sclerosis?

Balo’s concentric sclerosis is a histological variant of MS which used to be regarded as a distinct form of the disease. Histological examination of the brain shows sharply defined concentric rings of demyelination alternating with bands of unaffected myelin, giving an ‘onion skin’ appearance (Fig. 14.10).

Do MS lesions enhance on MRI?

Gadolinium-enhanced T1-weighted MRI scans can depict acute, active MS lesions. These appear as enhancing white matter lesions; the presence of an enhancing lesion has been shown to increase the specificity for MS.

Can MS lesions be anywhere in the brain?

Lesions can be seen anywhere in the brain parenchyma, but there are certain areas in which they are typical for MS. Characteristic sites are in the periventricular region and juxtacortical white matter.

What does Balo mean?

balo (balô) to try; to attempt.

What is a BALO effect?

While multiple sclerosis typically is a disease that waxes and wanes, Balo Disease is different in that it tends to be rapidly progressive. Symptoms may include headache, seizures, gradual paralysis, involuntary muscle spasms, and cognitive loss.

Can MS lesions be in the frontal lobe?

MS lesions developed preferentially in the supratentorial brain, particularly the frontal lobe and the sublobar region.

Do MS lesions come and go?

“Paradoxically, we see that lesion volume goes up in the initial phases of the disease and then plateaus in the later stages,” Zivadinov says. “When the lesions decrease over time, it’s not because the patient lesions are healing but because many of these lesions are disappearing, turning into cerebrospinal fluid.”

How many brain lesions are normal with MS?

An “average” number of lesions on the initial brain MRI is between 10 and 15. However, even a few lesions are considered significant because even this small number of spots allows us to predict a diagnosis of MS and start treatment.

What is Baló’s concentric sclerosis?

Baló’s concentric sclerosis is often regarded as a rare variant of multiple sclerosis. Patients with this disorder present with acute or subacute neurological deterioration, with MRI showing one or more concentrically multilayered ring-like lesions usually in the cerebral white matter. Historically, … Baló’s concentric sclerosis

Which MRI findings are characteristic of Baló’s concentric sclerosis (BCS)?

Patients with this disorder present with acute or subacute neurological deterioration, with MRI showing one or more concentrically multilayered ring-like lesions usually in the cerebral white matter. Historically, Baló’s concentric sclerosis was thought fatal in all cases.

What is the average age of onset of Baló’s concentric sclerosis?

The average age of onset of Baló’s concentric sclerosis is 34 years (range 3–62 years). Balo’s disease showing benign clinical course and co-existence with multiple sclerosis-like lesions in Chinese.

What is balbaló lesion?

Baló lesions can be mistaken for a brain tumour, such as glioblastoma multiforme or primary CNS lymphoma, and some patients undergo a brain biopsy to exclude a neoplastic lesion. Other differential diagnoses include infarction, brain abscess, and tumefactive demyelination.