What is Ag85A?

What is Ag85A?

The Ag85 complex is a 30–32 kDa family of three proteins (Ag85A, Ag85B, and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of cord factor.

What is the mechanism of tuberculosis?

tuberculosis is transmitted through the air, not by surface contact. Transmission occurs when a person inhales droplet nuclei containing M. tuberculosis, and the droplet nuclei traverse the mouth or nasal passages, upper respiratory tract, and bronchi to reach the alveoli of the lungs (Figure 2.2). M.

What is the host of tuberculosis?

Mycobacterium tuberculosis causes tuberculosis (TB) and is a leading infectious cause of death in adults worldwide [1]. The human host serves as a natural reservoir for M. tuberculosis. (See “Epidemiology of tuberculosis”.)

How does TB exit the body?

TB is caused by the bacterium M. tuberculosis. It spreads person to person when an infected individual coughs or sneezes out the bacteria, spreading it through the air to be breathed in by others.

Who is susceptible TB?

Persons who have been Recently Infected with TB Bacteria Persons who have immigrated from areas of the world with high rates of TB. Children less than 5 years of age who have a positive TB test. Groups with high rates of TB transmission, such as homeless persons, injection drug users, and persons with HIV infection.

What is the function of Mycobacterium ag85?

Mycobacterium Ag85 complex consists of Ag85A, Ag85B, and Ag85C, which play an important role in cell wall biosynthesis by catalyzing the synthesis of the cord factor (trehalose 6,6′-dimycolate, TDM) by mycolyltransferase activity and serve as fibronectin-binding proteins that interact with host macrophage to trigger host immune response23,24.

What is the antigen 85 complex of Mycobacterium tuberculosis?

The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis. Microbiol Rev. 1992;56:648–661. [PMC free article][PubMed] [Google Scholar] 40. Wolff J A, Malone R W, Williams P, et al. Direct gene transfer into mouse muscle in vivo.

How many strains of ag85b have the same gene sequence?

In the gene sequence of Ag85B, position 714 presented higher polymorphisms, as 93 strains owned an sSNPs (C-A). Six strains, i.e. four CAS family strains, one Beijing strain and one New strain presented same nonsynonymous mutation (G472A) in gene sequence of antigen Ag85C. Changes in T/B cell epitopes

What is the difference between ag85a and ag85b?

Ag85A and Ag85B owned both T cell epitopes and B cell epitopes, while Ag85C only had three T cell epitopes (See Figure ​Figure1).1). For Ag85A and Ag85B, some epitopes were both T cell epitopes and B cell epitopes.