What is a non-Germinomatous germ cell tumor?
Nongerminomatous germ cell tumors (NGGCTs) can consist of one malignant NGGCT type (e.g., embryonal carcinoma, yolk sac tumor, endodermal sinus tumor, or choriocarcinoma) or contain multiple elements of GCT components, including teratomatous or germinomatous constituents.
What is non-Germinomatous?
Germinomas: These are pure germ cell tumors. They respond well to treatment. Non-germinomatous tumors: These tumors secrete chemicals into the spinal fluid and bloodstream. They require more intensive treatment than germinomas.
Is Germinoma benign or malignant?
Germinoma. This is a slow-growing germ cell tumor. It is cancer (malignant).
What is a ependymoma?
An ependymoma is a primary central nervous system (CNS) tumor. This means it begins in the brain or spinal cord. To get an accurate diagnosis, a piece of tumor tissue will be removed during surgery, if possible. A neuropathologist should then review the tumor tissue.
What causes Germinoma?
Germinomas are rare tumors that primarily occur in children and adolescents. These tumors arise from germ cells, which normally become eggs or sperm after migrating to the ovaries or testes during fetal development. Germinomas occur when these germ cells fail to migrate to the proper location and continue dividing.
What is germinoma and what causes it?
What causes germinoma? No one really knows the cause of why germ cells, which during normal development of the baby travel to the ovum (egg) in the female and to the testis (sperm) in boys don’t go to the right place. What are the symptoms of germinoma?
What are non-germinomatous germ cell tumors (secreting tumors)?
Non-germinomatous germ cell tumors are also called “secreting tumors” because they may secrete alpha-fetoprotein (a protein produced during pregnancy) or a hormone called human chorionic gonadotropin (hCG). The secretion of these chemicals into the spinal fluid and bloodstream requires a more intensive treatment plan than pure germ cell tumors.
How many types of germinoma are there?
There are two main types (Germinomas and Non-germinomatous germ cell tumors- which have some sub-types) which respond differently to treatment. What causes germinoma?
Is there an effective treatment regimen for nongerminomatous germ-cell tumors?
Nongerminomatous germ-cell tumors are an invariably fatal subgroup within the pediatric pineal region germ-cell tumors. There is no effective, established therapeutic regimen. We report the treatment regimen for three children diagnosed with this highly aggressive tumor entity.
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