What drugs cause ototoxicity and nephrotoxicity?
It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity.
What causes ototoxicity and nephrotoxicity?
The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment.
What drugs cause ototoxicity?
List of Ototoxic Medications
- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including aspirin, ibuprofen, and naproxen.
- Certain antibiotics, including aminoglycosides.
- Certain cancer medications.
- Water pills and diuretics.
- Quinine-based medications.
What does it mean if a drug is Ototoxic?
Ototoxicity is when a person develops hearing or balance problems due to a medicine. This can happen when someone is on a high dose of a drug that treats cancer, infections, or other illnesses. When doctors find ototoxicity (oh-tuh-tok-SISS-ih-tee) early, they may be able to prevent it from getting worse.
Which drug is nephrotoxic?
The nephrotoxic effects of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin B, beta-lactam antibiotics and indomethacin are reviewed. These drugs were chosen because they are among the most frequent causes of renal injury in children. In addition, their nephrotoxicity is caused by different mechanisms.
Is doxycycline an ototoxic drug?
Mechanisms of Drug-Induced Ototoxicity Drugs associated with tinnitus include salicylates, quinine, streptomycin, neomycin, indomethacin, doxycycline, furosemide, metals, and caffeine. Ototoxicity at therapeutic dosing of most of the drugs listed below is unlikely.
Which Antitubercular drugs may cause ototoxicity?
The possible ototoxic effect of kanamycin, streptomycin and a standard anti-TB drug combination, used in the treatment of 92 TB patients (7-71 years old), was examined by measuring the highest audible electric bone conduction frequency before and after treatment, using an Audimax 500 audiometer.
What are five common medications that are potentially ototoxic and may cause hearing loss?
Ototoxic medicines that may cause hearing loss include aminoglycosides, macrolide antibiotics, antimalarials, platinum-based antineoplastic agents, anti-inflammatory medicines and loop diuretics (Table 1)2.
Is ibuprofen ototoxic?
While experts have long known that high doses of aspirin can damage hearing, they’ve recently discovered that even moderate doses can be ototoxic. Ditto for other nonsteroidal anti-inflammatory drugs such as naproxen (Aleve), ibuprofen (Advil) and diclofenac (Voltaren).
Is Piperacillin Tazobactam nephrotoxic?
Piperacillin/tazobactam (TZP) has been associated with nephrotoxicity in patients receiving vancomycin. Its impact on nephrotoxicity in patients with Gram-negative bacteraemia (GNB) is unclear. This study evaluated the impact of TZP on nephrotoxicity in patients with GNB.
Are NSAIDs nephrotoxic drugs?
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease in glomerular filtration rate, increase the risk of NSAID-related nephrotoxicity.
Which antibiotics are ototoxic?
ANTIBIOTICS WITH GOOD EVIDENCE FOR OTOTOXICITY
| Drug | Vestibulotoxicity | Toxic Level |
|---|---|---|
| Polymyxin B | In ear drops | |
| Streptomycin | very toxic | |
| Tobramycin | Yes | Less toxic than Gentamicin |
| Vancomycin | nontoxic or rarely toxic | synergistic with gentamicin |
Can antibiotics cause nephrotoxicity and ototoxicity?
It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity. The factors that selectively predispose the kidney and inner ear to the toxic effects of these agents as well as the me …
What medications can cause ototoxicity?
Other common medications that can cause ototoxicity include the following: Certain anticonvulsants. Tricyclic antidepressants. Anti-anxiety medications. Antimalarial medications.
Which medications cause nephrotoxicity?
A number of medications maintain higher potential for causing kidney injury on the basis of their more significant innate nephrotoxicity. These drugs, which include the aminoglycosides, amphotericin B, the polymyxins, and cisplatin, may cause kidney injury with therapeutic doses and brief durations of exposure 34).
How can medications with ototoxic effects be minimized?
Maintaining blood levels of the medications and performing serial audiograms can minimize their toxic effects. The ototoxic effects of these medications are enhanced in patients who are already taking other ototoxic medications such as the aminoglycoside antibiotics or loop diuretics.
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