What are the side effects of XIAFLEX?
Pain, swelling, bruising, bleeding, redness, itching at or around the injection site may occur. Swollen, painful areas in the elbow and underarm (swollen lymph nodes) may also occur when this medication is injected in the hand. If any of these effects persist or worsen, tell your doctor promptly.
Are collagenase injections painful?
Conclusions: Collagenase Clostridium histolyticum injection for treating Dupuytren contracture can be a painful process.
What is injectable collagenase?
Collagenase Clostridium histolyticum injection (Xiaflex) is used to treat Dupuytren’s contracture (a painless thickening and tightening of tissue [cord] beneath the skin in the palm of the hand, which may make it difficult to straighten one or more fingers) when a cord of tissue can be felt upon examination.
What is the most common side effect after a single collagenase treatment?
The most frequently reported adverse drug reactions (≥ 25%) in the XIAFLEX clinical trials in patients with Dupuytren’s contracture included edema peripheral (mostly swelling of the injected hand), contusion, injection site hemorrhage, injection site reaction, and pain in the treated extremity.
How much do XIAFLEX injections cost?
The cost for Xiaflex injectable powder for injection 0.9 mg is around $5,687 for a supply of 1 powder for injection, depending on the pharmacy you visit….Injectable Powder For Injection.
Quantity | Per unit | Price |
---|---|---|
1 | $5,686.78 | $5,686.78 |
How safe is XIAFLEX?
XIAFLEX can cause serious side effects, including: Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection.
What is the function of collagenase?
Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium.
How successful is XIAFLEX?
Studies have shown 34% improvement in penile curvature in men who underwent treatment with Xiaflex injection compared to 18% improvement in men treated with saline injection. In a study of 832 men, three men had penile fracture.
What is injection collagenase clostridium histolyticum?
Collagenase clostridium histolyticum injection is used to treat Dupuytren’s contracture with a palpable cord. It is also used to treat Peyronie’s disease with a palpable plaque and curvature deformity in men.
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