What are the adverse effects of nitroglycerin?
Advertisement
- Bloating or swelling of the face, arms, hands, lower legs, or feet.
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.
- difficult or labored breathing.
- feeling faint, dizzy, or lightheadedness.
- feeling of warmth or heat.
What is the most serious side effect of nitroglycerin?
Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, fast/irregular/pounding heartbeat. A very serious allergic reaction to this drug is rare.
Can you build a tolerance to nitroglycerin?
All organic nitrate regimens using frequent doses of long-acting nitrates (3 or more times daily), continuous delivery systems [transdermal nitroglycerin (glyceryl trinitrate) patches or continuous intravenous infusions of nitroglycerin] or long-acting (sustained release) preparations will result in partial or complete …
What happens when you take too much nitroglycerin?
Overdose symptoms may include a throbbing headache, confusion, pounding heartbeats, vision problems, vomiting, bloody diarrhea, sweating, clammy skin, blue lips, weak or shallow breathing, loss of movement, seizure, or fainting.
What is the action of nitroglycerin?
The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds.
Does nitroglycerin decrease blood pressure?
Taking nitroglycerin can lower your blood pressure, which could cause you to pass out if you are standing up. For sudden episodes of angina, use nitroglycerin in a tablet or liquid spray form.
What causes nitroglycerin tolerance?
The free radical hypothesis of nitrate tolerance They demonstrated that tolerance to nitroglycerin was dependent on the endothelium and went on to hypothesize that the increased free radical production, by scavenging NO released by the nitrate, was the mechanism underlying the development of tolerance.
How do I lower my tolerance to transdermal nitroglycerin?
These results confirm previous studies showing a high degree of tolerance during continuous therapy with nitroglycerin patches and suggest that tolerance can be prevented by 12-hour-daily intermittent therapy.
What are the contraindications of nitroglycerin?
The contraindications of nitroglycerine therapy include:
- Allergic reactions to nitroglycerin are extremely rare, but reports do exist.
- Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.
What drug decreases the absorption of nitroglycerin?
Tricyclic antidepressants (amitriptyline, desipramine, doxepin, others) and anticholinergic drugs may cause dry mouth and diminished salivary secretions. This may make dissolution of sublingual nitroglycerin difficult.
What is a contraindication to administering nitroglycerin?
Nitroglycerin is contraindicated in patients that have reported allergic symptoms to the medication. Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.
What are the side effects of nitroglycerin?
Check with your doctor immediately if any of the following side effects occur while taking nitroglycerin: Bloating or swelling of the face, arms, hands, lower legs, or feet. burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings. difficult or labored breathing.
How to prevent tolerance to nitrates?
How to prevent it or minimize its effect Continuous therapy with nitrates rapidly produces tolerance along with loss or diminution of circulatory, antianginal, and anti-ischemic effects. Development of tolerance can be avoided by various approaches. In patients with stable angina, intermittent use of nitrates with long nitrate-free interva …
What should I do if I overdose while taking nitroglycerin?
Get emergency help immediately if any of the following symptoms of overdose occur while taking nitroglycerin: Some side effects of nitroglycerin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
How is the effectiveness of nitroglycerin measured?
When administered sublingually, nitroglycerin’s effectiveness is typically subjectively measured via the resolution of symptoms; angina, hypertension, CHF, among others. In the event of overdose, monitoring of vital signs may be necessary to monitor the hemodynamic effects of nitroglycerin.
0