Is EBV associated with nasopharyngeal carcinoma?
Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV) infection in regions in which it is endemic, including Southern China and Southeast Asia. The high mortality rates of NPC patients with advanced and recurrent disease highlight the urgent need for effective treatments.
What cell type does EBV cause nasopharyngeal carcinoma in?
The association of EBV with epithelial cell tumors, specifically nasopharyngeal carcinoma (NPC) and EBV-positive gastric carcinoma (EBV-GC), is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic changes.
What is EBV VCA IgA positive?
A positive serum IgA VCA titer indicates previous repeated infection by the virus or frequent reactivation of latent EBV in B cells. This has been used as a screening tool to identify subjects at high risk of NPC,4,5 as well as being a diagnostic criteria for undifferentiated NPC.
What is EBV EA IgA?
For your information, expression of EBV (Epstein Barr Virus) antibody EA-IgA is among the examination in the implication of nasopharyngeal carcinoma diagnosis. However, other physical examination and complete history taking should be done before eliciting a diagnosis.
What are normal EBV numbers?
Optimal Result: 0 – 17.9 U/mL. EBV-VCA, IgG is an antibody (protein) that is produced by the body in an immune response to an Epstein-Barr virus antigen. EBV stands for Epstein-Barr virus. Epstein-Barr virus is a virus that typically causes a mild to moderate illness.
Why is my EBV IgG so high?
The presence of VCA IgG antibodies indicates that an EBV infection has occurred at some time recently or in the past. The presence of VCA IgM antibodies and the absence of antibodies to EBNA mean that the infection has occurred recently. The presence of antibodies to EBNA means that the infection occurred in the past.
How do you read Epstein Barr results?
Understanding the results
- If the antibody called VCA IgG is present, the Epstein-Barr virus has occurred at some time recently or in the past.
- If the VCA IgM antibody is present without the Epstein-Barr nuclear antigen (EBNA), the virus is likely to be currently active or occurred very recently.
What is stage 4 nasopharyngeal carcinoma?
In stage IVB, cancer has spread beyond the lymph nodes in the neck to distant lymph nodes, such as those between the lungs, below the collarbone, or in the armpit or groin, or to other parts of the body, such as the lung, bone, or liver.
Is the Epstein-Barr virus Iga-VCA titer sensitive for the diagnosis of nasopharyngeal carcinoma?
Sensitivity and specificity of Epstein-Barr virus IGA titer in the diagnosis of nasopharyngeal carcinoma: a three-year institutional review Although the EBV IgA-VCA titer is sensitive for the diagnosis of NPC, it should not be used as the sole means of screening for NPC in a population in which NPC is endemic.
Does EBV-DNA have a role in the diagnosis of nasopharyngeal carcinoma?
Numerous individual studies have investigated the diagnostic value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection for nasopharyngeal carcinoma (NPC), but the conclusions remain controversial. This meta-analysis aimed to determine the value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection in the diagnosis of NPC.
Which IgA antibodies are used to screen for nasopharyngeal carcinoma?
Background: IgA antibody titers to the Epstein-Barr virus (EBV) viral capsid antigen (EBV IgA-VCA) and to the EBV early antigen (EBV IgA-EA) are used to screen for nasopharyngeal carcinoma (NPC).
Is Epstein-Barr virus associated with nasopharyngeal carcinoma?
Abstract. The association of EBV with epithelial cell tumors, specifically nasopharyngeal carcinoma (NPC) and EBV-positive gastric carcinoma (EBV-GC), is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic changes.
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