How is ocular cicatricial pemphigoid diagnosed?

How is ocular cicatricial pemphigoid diagnosed?

Therefore, the clinical diagnosis of cicatricial pemphigoid is made when there is progression of a symblepharon without a history of local radiation or severe perennial allergic conjunctivitis. Diagnosis can be confirmed by conjunctival biopsy showing linear antibody deposition on the basement membrane.

Is ocular cicatricial pemphigoid an autoimmune disease?

Abstract: : Background: Ocular Cicatricial Pemphigoid (OCP) is a progressive autoimmune disorder, occurring late in life and characterized by recurrent episodes of inflammation, blistering and progressive conjunctival fibrosis that damages normal eye architecture and can lead to blindness; however the etiology of this …

What is OCP in ophthalmology?

Ocular cicatricial pemphigoid (OCP) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes.

What is OCP test for eyes?

Conjunctival biopsy A definitive diagnosis of ocular cicatricial pemphigoid (OCP) is made by demonstration of linear deposition of immunoreactants (eg, IgG, IgA, complement component C3 or C4) at the BMZ of the biopsy specimen of inflamed conjunctiva using immunofluorescent or immunoperoxidase technique.

What does the word Cicatricial mean?

pl. cic·a·tri·ces (sĭk′ə-trī′sēz, sĭ-kā′trĭ-sēz′) A scar left by the formation of new connective tissue over a healing sore or wound.

Can pemphigoid affect the eyes?

Ocular Citatrical Pemphigoid/Mucous Membrane Pemphigoid The inflammatory lesions on the ocular surface may result in scarring, loss of tear film, adhesions of the lids to the eyeball, corneal ulcers, and perforation. The frequent scarring that often occurs in this condition can lead to severe vision loss.

What is the cause of Cicatricial alopecia?

Cicatricial alopecia is primarily caused by inflammation that damages the hair follicle, although the damage may also be caused by a trauma such as a burn or serious infection. The inflammation could involve different types of cells, including lymphocytes, natural killer cells, or a combination of cell types.

Ocular cicatricial pemphigoid (OCP) is an autoimmune disease which clinically develops as progressive subepithelial conjunctival fibrosis and, if not diagnosed and treated early, it usually progresses to severe corneal scarring and neovascularization which can ultimately lead to blindness in up to one third of patients[1]–[2].

What is the adjuvant therapy for ocular cicatricial pemphigoid (CP)?

Pentoxifylline (anti-tumor necrosis factor drug): effective adjuvant therapy in the control of ocular cicatricial pemphigoid. Eur J Ophthalmol. 2011;21(5):529–537. [PubMed] [Google Scholar]

What is the treatment strategy for osteoarthritis of the eye (OCP)?

As a systemic autoimmune disease with the possibility of blindness, the treatment strategy for OCP is currently based on systemic and local immunosuppressive therapy according to the clinical severity and disease progression[9],[21].