How do you reconstitute daptomycin?

How do you reconstitute daptomycin?

Ensure that all CUBICIN powder is wetted by gently rotating the vial. Allow the wetted product to stand undisturbed for 10 minutes. Gently rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution.

Can you mix daptomycin with sterile water?

Reconstituted CUBICIN RF is compatible with Sterile Water for Injection, Bacteriostatic Water for Injection, and 0.9% sodium chloride injection.

Is daptomycin compatible with lactated ringers?

Daptomycin is compatible with 0.9% sodium chloride injection and lactated Ringer’s injection and is not compatible with dextrose-containing diluents.

Is daptomycin bacteriostatic or bactericidal?

Daptomycin is a useful option for the treatment of Gram-positive infections owing to its strong bactericidal activity.

Is daptomycin compatible with saline?

CUBICIN is compatible with 0.9% sodium chloride injection and lactated Ringer’s injection. CUBICIN is not compatible with dextrose-containing diluents. CUBICIN should not be used in conjunction with ReadyMED® elastomeric infusion pumps.

How do you mix linezolid?

The liquid form of linezolid should be gently mixed by turning the bottle upside down 3 to 5 times before each dose. Do not shake this product. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Is daptomycin compatible with normal saline?

Our results suggest that daptomycin reconstituted vials (50 mg/mL in normal saline) and infusion solutions (5.6 and 14 mg/mL in normal saline) are physicochemically stable over a period of at least 1 week at 2–8°C.

How should the contents of a daptomycin for injection be reconstituted?

The contents of a Daptomycin for Injection vial should be reconstituted, using aseptic technique, to 50 mg per mL as follows: 1. To minimize foaming, AVOID vigorous agitation or shaking of the vial during or after reconstitution.

What is the USP code for Daptomycin RF?

CUBICIN RF (daptomycin for injection) is supplied as a sterile pale yellow to light brown lyophilized powder in a single-dose 10 mL vial containing 500 mg of daptomycin: Package of 1 (NDC 67919-012-01). Store original packages at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]

How do you dilute daptomycin 500 mg?

Daptomycin (Cubicin or generics): Reconstitute single-dose vial containing 500 mg of daptomycin with 10 mL of 0.9% sodium chloride injection to provide solution containing 50 mg/mL. Add the diluent using beveled sterile transfer needle (≤21 gauge) or needleless device; direct diluent toward vial wall.

What is the molecular weight of daptomycin in a vial?

26 ; the molecular weight is 1620.67. Daptomycin for Injection is supplied in a single-dose vial as a sterile, preservativefree, pale yellow to light brown, lyophilized cake – containing approximately 350 mg of daptomycin for intravenous (IV) use following reconstitution with 0.9% sodium chloride injection Dosage and Administration (2.5) [see ]