How do they treat HER2-negative breast cancer?

How do they treat HER2-negative breast cancer?

Hormonal therapy is considered the standard initial treatment for HER2-negative metastatic breast cancer that is also hormone receptor-positive, and is often given in combination with targeted therapy. However, chemotherapy may also be given. A clinical trial may also be an option for treatment at any stage.

Is chemo recommended for HER2-negative?

Many women with hormone-positive, HER2-negative, lymph node-negative early-stage breast cancer who have intermediate risk of cancer recurrence do not need chemotherapy. The exception is that some women who are younger than 50 may benefit when chemotherapy is added to hormone therapy.

Is there an alternative to Herceptin?

Alternatives to Herceptin do exist for patients with HER2- positive breast cancer; they include Tykerb (lapatinib), a dual tyrosine kinase inhibitor available for the treatment of advanced HER2-positive breast cancer that has stopped responding to anthracyclines, taxanes and Herceptin.

Does Herceptin work on HER2-negative?

The protein HER2 plays a role even in breast cancers that would traditionally be categorized as HER2-negative. The drug trastuzumab (Herceptin), which targets HER2, may have an even greater role for treating breast cancer and preventing its spread.

What does it mean if you are HER2-negative?

What HER2-negative means. If breast cancer cells don’t have abnormal levels of HER2 proteins, the breast cancer is considered HER2-negative. Even if your cancer is HER2-negative, it may still be estrogen-positive or progesterone-positive. Whether or not it’s hormone-positive also affects your treatment options.

What does it mean to be HER2-negative?

Can you get Herceptin without chemo?

Certain women age 70 to 80 may be able to skip chemotherapy after surgery for early-stage HER2-positive disease and be treated only with Herceptin (chemical name: trastuzumab), according to a study.

Does tamoxifen work on HER2?

The researchers said the results suggest that some strongly estrogen-receptor-positive breast cancers that are also HER2-positive may be more responsive to anti-estrogen treatments, such as tamoxifen or the aromatase inhibitors, than they are to anti-HER2 treatments, such as Herceptin.

Is HER2 negative good?

There is, however, a greater risk of relapse and metastasis with a positive HER2 status, and survival rates are somewhat lower than for HER2 negative but estrogen receptor-positive tumors. People with HER2 positive tumors are less likely to respond to breast cancer chemotherapy than those who are negative.

Why is triple negative breast cancer so hard to treat?

Triple-negative breast cancer is different from the more common types of breast cancer. It is harder to treat and much more aggressive. Because it is aggressive and rare, fewer treatment options are available. It also tends to have a higher rate of recurrence.

Is surgery the best option for triple negative breast cancer?

Surgery is sometimes recommended to treat triple negative breast cancer, which occurs when cancerous tumors or masses of the breast test negative for hormone epidermal growth factor receptor 2 (HER-2), estrogen receptors (ER) and progesterone receptors (PR).