Does acetylsalicylic acid react with water?
Aspirin can undergo hydrolysis, making it not as effective if it’s exposed to water for extended periods of time. The technical name of the active ingredient in aspirin is acetylsalicylic acid. When it reacts with water, we end up with two products, salicylic acid and acetic acid.
Why is water added in aspirin synthesis?
The mixture is heated to form the acetylsalicylic acid (C9H8O4) and acetic acid (C2H4O2). After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting temperature measured.
What is the balanced chemical equation for salicylic acid?
The equation for this reaction is: C7H6O3 + C4H6O3 → C9H8O4 + CH3COOH Calculate the maximum mass of aspirin that could be made from 100 g of salicylic acid.
What is the solubility of aspirin in water?
Aspirin is slightly soluble in water: the solubility of aspirin in water is 0.33 grams per 100 mL water at room temperature.
Is dissolving aspirin in water a chemical change?
Aspirin tablets fizz when put into water. This is the result of two chemicals undergoing a chemical reaction. The chemicals are sodium bicarbonate (which is actually baking soda) and citric acid (acid found in fruit).
Is acetylsalicylic acid soluble in water?
It has a limited solubility in water, which amounts to 2–4 mg/mL and its solubility varies significantly with temperature . Aspirin is more soluble in ethanol, ethyl ether, chloroform, sodium hydroxide solution, and sodium carbonate solution than in water.
Why is acetylsalicylic acid not soluble in water?
Aspirin, or acetylsalicylic acid, or 2-hydroxybenzoic acid 2 carboxyphenyl ester, has a benzene ring, (C6H6) which is hydrophobic (water-hating), and this portion of the molecule does not interact with water.
Is aspirin soluble in water?
Aspirin is only slightly soluble in water so if you add it to the reaction mixture the product would rather clump together than be in the water phase. This causes the solid to begin to form or ‘precipitate’.
How is acetylsalicylic acid prepared from salicylic acid?
The Chemistry of Aspirin (acetylsalicylic acid) Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.
How do you make acetylsalicylic acid?
SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. H2SO4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.
What is the reaction equation for acetylsalicylic acid and acetic acid?
Very small test tube Reaction Equations: Salicylic acid + acetic anhydride –> acetylsalicylic acid + acetic acid (C7H6O3) + (C4H6O3) –> (C9H8O4) + (C2H4O2) References: ———————– [i] [ii] Chemicalland: Lifestyle. (2008). ACETYLSALICYLIC ACID [online].
How to synthesize aspirin from salicylic acid?
The experiment starts by combining such chemicals such as salicylic acid and acetic anhydride. The synthesis of aspirin is classified as an esterification reaction. This is a substitution reaction where the alcohol group from salicylic acid reacts with ascetic anhydride to form an ester, (acetylsalicylic acid) which is commonly known as Aspirin.
Why doesn’t salicylic acid react with acetic anhydride?
Since the stoichiometric molar ratio of salicylic acid to acetic anhydride is 1:1 and the actual molar ratio is 0.191 (< 1), there is insufficient salicylic acid to react with the acetic anhydride.
How many moles of salicylic acid are in one mole of acetic anhydride?
Therefore we are able to calculate the number of moles of salicylic acid using the equation: m = n/ Mr Moles of acetic anhydride 50/138 = 0. 3623 mol The chemical name for Aspirin is Acetylsalicylic Acid. A balanced equation for the synthesis of Aspirin from Salicylic Acid and Acetic Anhydride is the following: