Can you reverse apomorphine?

Can you reverse apomorphine?

Previous data have shown that apomorphine-induced respiratory depression can be reversed by the opiate antagonist, naloxone.

What does apomorphine do to the body?

Apokyn (apomorphine hydrochloride injection) is a dopamine agonist, which works by helping restore the balance of dopamine in the brain, used to treat “wearing-off” episodes (muscle stiffness, loss of muscle control) in people with advanced Parkinson’s disease.

How does apomorphine work in Parkinsons?

Apomorphine is a strong type of dopamine agonist. Dopamine agonist drugs act like dopamine to stimulate nerve cells. These nerve cells then control movement and other body functions, to help reduce the symptoms of Parkinson’s.

Why is apomorphine called apomorphine?

Contrary to its name, apomorphine does not actually contain morphine or its skeleton, nor does it bind to opioid receptors. The apo- prefix relates to it being a morphine derivative (“[comes] from morphine”).

Does apomorphine make humans vomit?

Severe nausea and vomiting are commonly induced by apomorphine and can be controlled by pretreatment for a few days with oral or rectal domperidone 20 to 30 mg three times daily.

What is a contraindication for apomorphine?

Apomorphine should generally be avoided in patients with a major psychotic disorder such as those with a history of psychosis or schizophrenia due to the risk of exacerbating psychosis. In clinical studies, hallucinations were reported in clinical trials of both subcutaneous and sublingual apomorphine.

Does apomorphine cause depression?

Acute administration of apomorphine had no effect on psychomotor retardation or depressed mood in two patients with endogenous depression.

Where does the apomorphine act to cause the emesis?

APOMORPHINE (6.25-MG TABLETS). Apomorphine acts directly on the chemoreceptor trigger zone to induce emesis. Apomorphine is generally the emetic of choice because of its rapid onset and the ability to reverse its action.

How do you dispose of apomorphine?

Discard this type of pre-filled syringe if not used in 24 hours. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Is apomorphine an emetic?

Apomorphine acts directly on the chemoreceptor trigger zone to induce emesis. Apomorphine is generally the emetic of choice because of its rapid onset and the ability to reverse its action. Apomorphine is given at a dose of 0.02 to 0.04 mg/kg intravenously or intramuscularly.

Does apomorphine make you nauseous?

Nausea is very common with this medication. To decrease the risk of nausea, your doctor may direct you to start taking another medication (e.g., trimethobenzamide) 3 days before your first dose of apomorphine and to continue taking as directed for up to 2 months. Use this medication as prescribed.

How does apomorphine induce vomiting?

Apomorphine induces emesis by stimulating dopamine receptors in the brain’s CRTZ and also has effects on other receptors that are not related to emesis.