Can high Dilantin levels cause seizures?

Can high Dilantin levels cause seizures?

The NIH notes that very high levels of Dilantin may even lead to seizures, the same condition the drug is meant to control. Symptoms of Dilantin toxicity may include the following: Fast, uncontrollable eye movements or double vision (nystagmus) Dizziness, drowsiness, or confusion.

What is a toxic level of Dilantin?

Thirty to 40 mg/L: Ataxia, slurred speech, tremor, nausea, and vomiting. Forty to 50 mg/L: Lethargy, confusion, hyperactivity. Greater than 50 mg/L: Coma and seizures.

What happens if Dilantin levels are too low?

Your risk of seizures increases if you decrease your dose or stop taking Dilantin. Even a small increase in your dose can cause toxicity.

What are symptoms of high Dilantin levels?


  • Coma.
  • Confusion.
  • Staggering gait or walk (early sign)
  • Unsteadiness, uncoordinated movements (early sign)
  • Involuntary, jerky, repeated movement of the eyeballs called nystagmus (early sign)
  • Seizures.
  • Tremor (uncontrollable, repeated shaking of the arms or legs)
  • Sleepiness.

What is the major concern after administering phenytoin to a patient with seizure?

Nervous System: The most common adverse reactions encountered with phenytoin therapy are nervous system reactions and are usually dose-related. Reactions include nystagmus, ataxia, slurred speech, decreased coordination, somnolence, and mental confusion.

How often should Dilantin levels be checked?

A level can be taken 2-4 hours following an IV loading or top-up dose (12-24 hours for oral doses) and levels should then be monitored every 24 hours until control is achieved and concentration has stabilised.

What is the normal range for Dilantin levels?

The therapeutic range is 10-20 mcg/mL. Total phenytoin levels (mcg/mL) and typical corresponding signs and symptoms are as follows: Lower than 10 – Rare.

What would cause Dilantin levels to drop?

Drugs which may decrease phenytoin levels include: carbamazepine, chronic alcohol abuse, reserpine, and sucralfate. MobanĀ® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin.

What is a normal Dilantin level?

The therapeutic range is 10-20 mcg/mL. Total phenytoin levels (mcg/mL) and typical corresponding signs and symptoms are as follows: Lower than 10 – Rare. Between 10 and 20 – Occasional mild nystagmus.

What are normal levels for phenytoin?

The therapeutic ranges for most adults have been established at 10.0-20.0 mcg/mL for total phenytoin (bound plus unbound) and 1.0-2.0 mcg/mL for free phenytoin (unbound only). This reference range for unbound phenytoin (free) was established based on an assumed 10% unbound drug fraction.

How do you monitor Dilantin levels?

Laboratories often report the value in g/L instead (g/dL = g/L x 0.1). After a patient has received a loading dose of intravenous phenytoin, levels can be checked one hour after the dose. If loading is achieved by oral dosing, phenytoin levels can be checked 24 hours after the last dose10.

How does Dilantin prevent seizures?

Dilantin ( phenytoin) is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Dilantin is used to control seizures. Phenytoin does not treat all types of seizures, and your doctor will determine if it is the right medicine for you.

What happens when Dilantin level is too high?

Drowsiness, especially excessive drowsiness, is also a signal that Dilantin levels are too high. Dilantin toxicity can lead to involuntary jerking movements. These involuntary movements can involve the body, the face or the arms and legs.

Does Dilantin cause elevated liver enzymes?

There is no Elevated liver enzymes reported by people who take Dilantin yet. This review analyzes which people have Elevated liver enzymes with Dilantin. It is created by eHealthMe based on reports from FDA, and is updated regularly.

What is Dilantin toxicity, know its signs, symptoms, treatment?

The most common signs of Dilantin toxicity includes lethargy, dizziness, drowsiness and rapid eye movements. People who presume to have Dilantin toxicity must contact their healthcare provider immediately to alleviate the symptoms and treat the condition.